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Journal of Bacteriology, September 2005, p. 5861-5867, Vol. 187, No. 17
0021-9193/05/$08.00+0     doi:10.1128/JB.187.17.5861-5867.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

The yliA, -B, -C, and -D Genes of Escherichia coli K-12 Encode a Novel Glutathione Importer with an ATP-Binding Cassette

Hideyuki Suzuki,* Takashi Koyanagi, Shunsuke Izuka, Akiko Onishi, and Hidehiko Kumagai{dagger}

Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Oiwake-cho, Kitashirakawa, Sakyo-ku, Kyoto 606-8502, Japan

Received 28 April 2005/ Accepted 30 May 2005

Glutathione protects cells and organisms from oxygen species and peroxides and is indispensable for aerobically living organisms. Moreover, it acts against xenobiotics and drugs by the formation and excretion of glutathione S conjugates. In this study, we show that the yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a glutathione transporter with the ATP-binding cassette. The transporter imports extracellular glutathione into the cytoplasm in an ATP-dependent manner. This transporter, along with {gamma}-glutamyltranspeptidase, has an important role in E. coli growth with glutathione as a sole sulfur source.

* Corresponding author. Mailing address: Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Oiwake-cho, Kitashirakawa, Sakyo-ku, Kyoto 606-8502, Japan. Phone: 81-75-753-9233. Fax: 81-75-753-6275. E-mail: hideyuki{at}lif.kyoto-u.ac.jp.

{dagger} Present address: Research Institute of Natural Resources, Ishikawa Prefectural University, Nonoichi-cho, Ishikawa-gun, Ishikawa 921-8836, Japan.

Journal of Bacteriology, September 2005, p. 5861-5867, Vol. 187, No. 17
0021-9193/05/$08.00+0     doi:10.1128/JB.187.17.5861-5867.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Kurihara, S., Tsuboi, Y., Oda, S., Kim, H. G., Kumagai, H., Suzuki, H. (2009). The Putrescine Importer PuuP of Escherichia coli K-12. J. Bacteriol. 191: 2776-2782 [Abstract] [Full Text]  
  • Helbig, K., Bleuel, C., Krauss, G. J., Nies, D. H. (2008). Glutathione and Transition-Metal Homeostasis in Escherichia coli. J. Bacteriol. 190: 5431-5438 [Abstract] [Full Text]  
  • Yamada, C., Kijima, K., Ishihara, S., Miwa, C., Wada, K., Okada, T., Fukuyama, K., Kumagai, H., Suzuki, H. (2008). Improvement of the Glutaryl-7-Aminocephalosporanic Acid Acylase Activity of a Bacterial {gamma}-Glutamyltranspeptidase. Appl. Environ. Microbiol. 74: 3400-3409 [Abstract] [Full Text]  
  • Goswami, M., Jawali, N. (2007). Glutathione-mediated augmentation of {beta}-lactam antibacterial activity against Escherichia coli. J Antimicrob Chemother 60: 184-185 [Full Text]  


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