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J Bacteriol. 1962 January; 83(1): 169-174
Copyright © 1962, The Williams & Wilkins Company. All Rights Reserved.

UTILIZATION OF S-ADENOSYLMETHIONINE BY MICROORGANISMS1

Stanley K. Shapiro

a Division of Biological and Medical Research, Argonne National Laboratory, Argonne, Illinois

ABSTRACT

SHAPIRO, STANLEY K. (Argonne National Laboratory, Argonne, Ill.). Utilization of S-adenosylmethionine by microorganisms. J. Bacteriol. 83:169–174. 1962.—Two types of mutants of Aerobacter aerogenes that utilize S-adenosylmethionine for growth are described. One type also responds to methionine, 5'methylthioadenosine, or a combination of homocysteine and S-methylmethionine. The second type of mutant responds only to S-adenosylmethionine or a combination of adenine and S-ribosylmethionine. The most common type of methionine mutant is unable to utilize S-adenosylmethionine for growth. The mutants are able to utilize the compounds that support growth as the sole source of sulfur. S-Adenosylhomocysteine is not utilized for growth by any of the mutants of A. aerogenes described here. There are no significant differences between the mutants and the wild type in the enzymatic decomposition of S-adenosylmethionine or in the activity of the homocysteine transmethylases. S-Adenosylmethionine does not replace the methionine requirement of the lactic acid bacteria, although Lactobacillus arabinosus shows half-maximal growth with the sulfonium compound and homocysteine. S-Adenosylhomocysteine is not utilized for growth by these organisms.

FOOTNOTES

1 This work was performed under the auspices of the U. S. Atomic Energy Commission.

J Bacteriol. 1962 January; 83(1): 169-174
Copyright © 1962, The Williams & Wilkins Company. All Rights Reserved.





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