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J. Bacteriol. doi:10.1128/JB.01256-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Streptococcus pyogenes CovR/S Mediates Growth in Iron Starvation and in the Presence of the Human Cationic Antimicrobial Peptide LL-37

Barbara J. Froehlich, Christopher Bates, and June R. Scott

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Ga. 30322


  Abstract

We found that the global regulatory two-component signal transduction system, CovR/S, mediates the ability of GAS to grow under two stresses encountered during infection: iron starvation and the presence of LL-37. We also showed that CovRS regulates transcription of the multi-metal transporter operon important for GAS growth in low iron.






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